Name: TC-MCH 7c
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HIT ID:HIT100167867
Cas No:864756-35-4
Common Name:TC-MCH 7c
IUPAC:4-[(4-fluorophenyl)methoxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1,2-dihydropyridin-2-one
IUPAC:4-[(4-fluorophenyl)methoxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1,2-dihydropyridin-2-one
InChI key:ANCFKYJMXNMYNZ-UHFFFAOYSA-N

Molecular Formula:C24H25FN2O3
Molecular Weight:408.473
Hydrogen Bond Donor (HBD):0
Hydrogen Bond Acceptor (HBA):4
LogP:3.746256
SMILES:Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
SMILES:Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1

TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.

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