Name: PTK7/β-catenin-IN-2
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT102960661
Cas No:902434-29-1
Common Name:PTK7/β-catenin-IN-2
IUPAC:3-[2-(4-chlorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]-N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}propanamide
IUPAC:3-[2-(4-chlorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]-N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}propanamide
InChIKey:JVQFIVIGXOMNNB-UHFFFAOYSA-N

Molecular Formula:C30H34Cl2N6O
Molecular Weight:565.54
Hydrogen Bond Donor (HBD):1
Hydrogen Bond Acceptor (HBA):5
LogP:5.0349
SMILES:Cc1nc2cc(nn2c(C)c1CCC(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1)-c1ccc(Cl)cc1
SMILES:Cc1nc2cc(nn2c(C)c1CCC(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1)-c1ccc(Cl)cc1

PTK7/β-catenin-IN-2 (compound 04967) acts as an inhibitor targeting both PTK7 and β-catenin, effectively preventing their interaction with an IC₅₀ of 5.6 μM and disrupting the Wnt/β-catenin signaling pathway. This interference supports its role in inhibiting cell growth reliant on Wnt signaling, exhibiting anticancer capabilities. Additionally, the compound displays an inhibitory effect on the binding of p53 to MDM2, with an IC₅₀ value of 157.1 μM ^[1].

Marketplace OffersShowing from 3 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~