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HIT103501903
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HIT103501903
  • HIT ID:HIT103501903
  • Cas No:421579-95-5
  • Common Name:Inhibitor #2714
  • IUPAC:ethyl 5-(4-fluorobenzenesulfonamido)-2-phenyl-1-benzofuran-3-carboxylate
    IUPAC:ethyl 5-(4-fluorobenzenesulfonamido)-2-phenyl-1-benzofuran-3-carboxylate
  • InChIKey:MCWZMIDUVZXGBW-UHFFFAOYSA-N
  • Molecular Formula:C23H18FNO5S
  • Molecular Weight:439.46
  • Hydrogen Bond Donor (HBD):1
  • Hydrogen Bond Acceptor (HBA):5
  • LogP:6.28
  • SMILES:CCOC(=O)c1c(oc2ccc(NS(=O)(=O)c3ccc(F)cc3)cc12)-c1ccccc1
    SMILES:CCOC(=O)c1c(oc2ccc(NS(=O)(=O)c3ccc(F)cc3)cc12)-c1ccccc1
  • Inhibitor #2714, a novel inhibitor of cell proliferation, effectively arrests the G2/M phase, reduces phosphorylated cell division cycle 25C (Cdc25C) levels, and enhances p53 expression. This compound inhibits lung cancer cell proliferation and angiogenesis, and induces apoptosis in vitro.
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