Name: WMS-1405
Rating: 4 (6 reviews)

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HIT ID:HIT218643370
Cas No:1232196-73-4
Common Name:WMS-1405
alias:WMS1405, WMS 1405, Me-NB1, MeNB1, Me NB1
alias:WMS1405, WMS 1405, Me-NB1, MeNB1, Me NB1
IUPAC:7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
IUPAC:7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
InChI key:NXWYICVCGHHJOR-UHFFFAOYSA-N

Molecular Formula:C21H27NO2
Molecular Weight:325.452
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1ccc2C(O)CN(CCCCc3ccccc3)CCc2c1
SMILES:COc1ccc2C(O)CN(CCCCc3ccccc3)CCc2c1

WMS-1405 is a derivative of ifenprodil. As a potent NR2B-selective NMDA receptor antagonist, it exhibits a Ki value of 5.4 nM. Synthesized through a central building block approach, WMS-1405 displays high NR2B affinity due to the specific distance between its basic nitrogen atom and phenyl residue. WMS-1405 has the potential to serve as an NMDA antagonist for excitotoxicity treatment.

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