Name: DOTA-NT-20.3
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218678304
Cas No:2253985-29-2
Common Name:DOTA-NT-20.3
alias:Ac-Lys-Pro-N-Me-Arg-Arg-Pro-Tyr-Tle-Leu-OH
alias:Ac-Lys-Pro-N-Me-Arg-Arg-Pro-Tyr-Tle-Leu-OH
IUPAC:6-bromo-N-[4-({2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-5-fluoropyrimidin-4-yl}amino)phenyl]pyridine-2-carboxamide
IUPAC:6-bromo-N-[4-({2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-5-fluoropyrimidin-4-yl}amino)phenyl]pyridine-2-carboxamide
InChIKey:YJGYJPZYSQTACG-OKILXGFUSA-N

Molecular Formula:C22H23BrFN7O
Molecular Weight:500.376
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:C[C@H]1CN(C[C@@H](C)N1)c1ncc(F)c(Nc2ccc(NC(=O)c3cccc(Br)n3)cc2)n1
SMILES:C[C@H]1CN(C[C@@H](C)N1)c1ncc(F)c(Nc2ccc(NC(=O)c3cccc(Br)n3)cc2)n1

68Ga-DOTA-NT-20.3 is an analogue of neurotensin (NTS) and acts as a ligand for 68Ga ions. In PET imaging, it demonstrates rapid tumor uptake and high contrast between tumor and background, along with fast clearance from the blood and moderate accumulation in the kidneys. Its pharmacokinetic and biodistribution properties are advantageous, producing high-quality PET images in mice with subcutaneous or orthotopic human pancreatic cancer xenografts. 68Ga-DOTA-NT-20.3 specifically binds to NTSR1 on pancreatic cancer cells and outperforms 18F-FDG in PET detection of adenocarcinoma.

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~