Name: Hinokiol
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HIT ID:HIT218678436
Cas No:
Common Name:Hinokiol
alias:8,11,13-Abietatriene-3,12-diol
IUPAC:1,1,4a-trimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,6-diol
IUPAC:1,1,4a-trimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,6-diol
InChIKey:ODFCWXVQZAQDSO-UHFFFAOYSA-N

Molecular Formula:C20H30O2
Molecular Weight:302.458
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(C)c1cc2CCC3C(C)(C)C(O)CCC3(C)c2cc1O
SMILES:CC(C)c1cc2CCC3C(C)(C)C(O)CCC3(C)c2cc1O

Hinokiol is a naturally occurring diterpenoid compound isolated from trees like Taiwania cryptomerioides. It inhibits voltage-gated sodium channels in a concentration- and state-dependent manner, with IC₅₀ values of 11.3 µM at a holding potential of -70 mV and 37.4 µM at -100 mV, shifting steady-state inactivation by 13 mV. This compound also modulates cell cycle arrest at the G0/G1 phase and induces apoptosis through the Hippo/YAP signaling pathway. Hinokiol is commonly used in research to study ion channel regulation, cell cycle control, and apoptotic mechanisms in neuronal and cancer cell models.

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