Name: Araguspongin B
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HIT ID:HIT218832601
Cas No:
Common Name:Araguspongin B
IUPAC:9,30-dioxa-11,25-diazapentacyclo[20.6.2.2^{8,11}.0^{10,15}.0^{25,29}]dotriacontane
IUPAC:9,30-dioxa-11,25-diazapentacyclo[20.6.2.2^{8,11}.0^{10,15}.0^{25,29}]dotriacontane
InChI key:PQYOPBRFUUEHRC-UHFFFAOYSA-N

Molecular Formula:C28H50N2O2
Molecular Weight:446.72
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:C1CC2CCCCCCC3CCN4CCCC(CCCCCCC5CCN(C1)C2O5)C4O3
SMILES:C1CC2CCCCCCC3CCN4CCCC(CCCCCCC5CCN(C1)C2O5)C4O3

Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 µM. This potency places it nearly on par with xestospongin C in obstructing the IP3 receptor's activity.

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