Name: 15(R)-HETE
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218832613
Cas No:
Common Name:15(R)-HETE
alias:15(R)-Hydroxyeicosatetraenoic Acid
IUPAC:15-hydroxyicosa-5,8,11,13-tetraenoic acid
IUPAC:15-hydroxyicosa-5,8,11,13-tetraenoic acid
InChI key:JSFATNQSLKRBCI-UHFFFAOYSA-N

Molecular Formula:C20H32O3
Molecular Weight:320.473
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O
SMILES:CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O

15(R)-HETE, a monohydroxy fatty acid, is synthesized from arachidonic acid via aspirin-acetylated COX-2, leading to the formation of specialized pro-resolving mediators 15(R)-lipoxin A4 and B4 through a transcellular mechanism involving 5-lipoxygenase (5-LO). Additionally, this compound is produced by the cytochrome P450 (CYP) isoform CYP2C9 and can be generated from arachidonic acid by COX-1 in human mast cells, where it accumulates due to its resistance to conversion into 15-KETE by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). As an agonist of PPARβ/δ, 15(R)-HETE induces the expression of a target gene in NIH3T3 cells, demonstrating its biological significance.

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~