Name: 15(R)-HETE
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HIT ID:HIT218832613
Cas No:
Common Name:15(R)-HETE
alias:15(R)-Hydroxyeicosatetraenoic Acid
IUPAC:15-hydroxyicosa-5,8,11,13-tetraenoic acid
IUPAC:15-hydroxyicosa-5,8,11,13-tetraenoic acid
InChIKey:JSFATNQSLKRBCI-UHFFFAOYSA-N

Molecular Formula:C20H32O3
Molecular Weight:320.473
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O
SMILES:CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O

15(R)-HETE is a stereoisomer of the 15-lipoxygenase arachidonic acid metabolite known to interact with specific subcellular binding sites. In competitive binding assays, 15(R)-HETE displaces [³H]-15(S)-HETE from its binding sites with lower affinity than the 15(S) isomer, where 15(S)-HETE itself exhibits a single class of high-affinity sites (Kd = 460 ± 160 nM, Bmax = 5.0 ± 1.1 nM) in membrane fractions. This compound is useful in structure-activity relationship studies examining the stereospecificity of eicosanoid binding and downstream signaling inhibition. Researchers employ 15(R)-HETE as a control or comparator to probe the molecular recognition requirements of 15-HETE-sensitive pathways in isolated cellular fractions.

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