Name: (±)5(6)-DiHET
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HIT ID:HIT218832642
Cas No:
Common Name:(±)5(6)-DiHET
alias:(±)5,6-DiHETrE
IUPAC:5,6-dihydroxyicosa-8,11,14-trienoic acid
IUPAC:5,6-dihydroxyicosa-8,11,14-trienoic acid
InChIKey:GFNYAPAJUNPMGH-UHFFFAOYSA-N

Molecular Formula:C20H34O4
Molecular Weight:338.488
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC=CCC=CCC=CCC(O)C(O)CCCC(O)=O
SMILES:CCCCCC=CCC=CCC=CCC(O)C(O)CCCC(O)=O

5(6)-DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5(6)-EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5(6)-EET, facilitating its measurement by utilizing the compound's conversion to 5(6)-δ-lactone in solution. Additionally, 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia.

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