Name: KH-4-43
Rating: 4 (6 reviews)

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HIT ID:HIT218832954
Cas No:
Common Name:KH-4-43
IUPAC:3-[1-(4-chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-chromen-4-one
IUPAC:3-[1-(4-chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-chromen-4-one
InChIKey:KDPAGFLLKCODNF-UHFFFAOYSA-N

Molecular Formula:C19H10ClF3N2O4
Molecular Weight:422.74
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Oc1ccc2c(oc(c(-c3cnn(c3)-c3ccc(Cl)cc3)c2=O)C(F)(F)F)c1O
SMILES:Oc1ccc2c(oc(c(-c3cnn(c3)-c3ccc(Cl)cc3)c2=O)C(F)(F)F)c1O

KH-4-43, an inhibitor of the E3 CRL4 ligase complex, demonstrates anticancer activity by targeting the core of the E3 CRL4. It exhibits a binding affinity (Kd) of 83 nM to the E3 ROC1-CUL4A CTD and 9.4 μM to the closely related ROC1-CUL1 CTD [1].

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