Name: Indium (III) thiosemicarbazone 5b
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HIT ID:HIT218832987
Cas No:
Common Name:Indium (III) thiosemicarbazone 5b
Common Name:Indium (III) thiosemicarbazone 5b
IUPAC:
IUPAC:
InChIKey:GMGJXQKTFHLNRA-UHFFFAOYSA-N

Molecular Formula:C10H15Cl2InN4OS
Molecular Weight:425.04
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:C[OH][In+3]12([Cl-])([Cl-])[S-]C(=N[N]1=CC1=[N]2C=CC=C1)N(C)C
SMILES:C[OH][In+3]12([Cl-])([Cl-])[S-]C(=N[N]1=CC1=[N]2C=CC=C1)N(C)C

Indium (III) thiosemicarbazone 5b is an anticancer compound demonstrating cytotoxicity against various cancer cell lines including A549, MCF-7 breast, cisplatin-resistant MCF-7/DDP breast, and Hl 7702 liver cancer cells, with IC₅₀ values of 2.41, 1.97, 2.11, and 8.95 µM, respectively. It effectively lowers PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo studies show that at a dosage of 2.5 µmol/kg, indium (III) thiosemicarbazone 5b significantly reduces tumor weight and volume in MCF-7/DDP mouse xenograft models. Furthermore, liposomes formulated with this compound promote apoptosis and pro-death autophagy in MCF-7/DDP cells, alongside notable reductions in tumor volume and weight, showcasing its potential as a therapeutic agent in cancer treatment.

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