抗癌活性化合物库

Anti-Cancer Active Compound Library

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力；并且表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

根据文献报道和有关公开资料，我们挑选了 4270 个具有已知抗癌活性的化合物组成抗癌活性库，可用于具体癌症的阳性对照及癌症机理的研究。希望我们在抗癌研究的路上，助您一臂之力！

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号： L2160

规格
1 mg
30 μL x 10 mM (in DMSO)
50 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)

化合物库咨询特别折扣，等您来咨询！

技术资料

产品描述

产品描述:
- 4270种具有抗肿瘤活性的化合物的特有集合，用于高通量、高内涵筛选；
- 是肿瘤发生机理研究、抗肿瘤药物筛选的有效工具；
- 靶点含PI3K、HDAC、mTOR、CDK、Aurora Kinase、JAK等；
- 结构多样，药效显著，可渗透细胞；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS检测技术保证产品高纯度和高质量，减少假阳性发生概率。
包装和储存:
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
- 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。

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化合物库组成

Apoptosis

Others

Autophagy

Antibacterial

Endogenous Metabolite

DNA/RNA Synthesis

NF-κB

CDK

PI3K

EGFR

ROS

Ras

VEGFR

Akt

Antibiotic

Parasite

Microtubule Associated

Topoisomerase

mTOR

Epigenetic Reader Domain

Antifungal

Caspase

Reactive Oxygen Species

Bcl-2 Family

ERK

FLT

Nucleoside Antimetabolite/Analog

Dehydrogenase

COX

PDGFR

STAT

Histone Methyltransferase

PARP

p38 MAPK

HDAC

FGFR

Estrogen Receptor/ERR

c-Met/HGFR

TNF

Wnt/beta-catenin

Cytochromes P450

HIV Protease

c-Kit

Ferroptosis

Src

Interleukin

Raf

MDM-2/p53

JAK

HSP

Phosphatase

Antioxidant

MMP

Virus Protease

Influenza Virus

Estrogen/progestogen Receptor

Kras

PKC

AMPK

Bcr-Abl

NO Synthase

ALK

Aurora Kinase

Androgen Receptor

PPAR

JNK

Nrf2

Calcium Channel

SARS-CoV

E1/E2/E3 Enzyme

MEK

P-gp

GSK-3

DUB

HIF/HIF Prolyl-Hydroxylase

FAK

IL Receptor

MAPK

TLR

PROTACs

p53

Mitophagy

TGF-beta/Smad

HSV

IGF-1R

DNA Alkylator/Crosslinker

Antiviral

c-RET

AChR

Mitochondrial Metabolism

Sirtuin

Drug Metabolite

Chk

Histone Demethylase

PDE

ATM/ATR

Lipoxygenase

Proteasome

TAM Receptor

Gamma-secretase

Potassium Channel

Tyrosine Kinases

HER

Trk receptor

c-Fms

Histone Acetyltransferase

DNA-PK

Cholinesterase (ChE)

Pim

Molecular Glues

S6 Kinase

Sodium Channel

PERK

Casein Kinase

Adrenergic Receptor

5-HT Receptor

Retinoid Receptor

Hedgehog/Smoothened

Transferase

Mdm2

HIF

ROS Kinase

Reductase

Smo

PLK

DNA Methyltransferase

GABA Receptor

PD-1/PD-L1

ADC Cytotoxin

Integrin

Serine Protease

IAP

Anti-infection

Fatty Acid Synthase

Kinesin

CXCR

Histamine Receptor

HBV

YAP

Aryl Hydrocarbon Receptor

PKA

DNA Alkylation

TRP/TRPV Channel

PDK

HCV Protease

Glutathione Peroxidase

Tyrosinase

Beta Amyloid

LPL Receptor

Antifolate

c-Myc

Phospholipase

S1P Receptor

IDO

Dopamine Receptor

Antifection

Ligands for E3 Ligase

Indoleamine 2,3-Dioxygenase (IDO)

Serine/threonin kinase

Isocitrate Dehydrogenase (IDH)

IκB/IKK

Carbonic Anhydrase

DNA

transporter

GPCR

BTK

Aromatase

DHFR

CSF-1R

Immunology/Inflammation related

Syk

Prostaglandin Receptor

MAO

IKZF

ATPase

NADPH

ROCK

CaMK

NOS

OXPHOS

Adenosine Receptor

DYRK

Rho

Cell Cycle Arrest

glycosidase

AhR

Monoamine Oxidase

Glutaminase

Survivin

Monocarboxylate transporter

Cysteine Protease

Photosensitizer

Glucosidase

IFNAR

Telomerase

RIP kinase

BCRP

STING

Progesterone Receptor

Ephrin Receptor

Reverse Transcriptase

Tie-2

Cholecystokinin Receptor

Acyltransferase

Amino Acids and Derivatives

MNK

iGluR

CCR

RANKL/RANK

Glucocorticoid Receptor

NOD-like Receptor (NLR)

Wee1

Methionine Adenosyltransferase (MAT)

Proton pump

Opioid Receptor

GPX

PAK

PAI-1

NOD

IRAK

MicroRNA

ABC Transporter

Bcl-6

Lipid

P2X Receptor

Somatostatin

Discoidin Domain Receptor (DDR)

Chloride channel

IRE1

Cannabinoid Receptor

GNRH Receptor

NAMPT

RAAS

Endothelin Receptor

ROR

Ligands for Target Protein for PROTAC

Glucokinase

Angiotensin-converting Enzyme (ACE)

Orphan Receptor

ATG

GluR

Necroptosis

PSMA

LPA Receptor

BMI-1

Thrombin

PYK2

UGT

HMG-CoA Reductase

p97

Leukotriene Receptor

Pyroptosis

PKM

Liver X Receptor

Myosin

FOXO

Neurokinin receptor

Galectin

MTH1

NMDAR

Hexokinase

Complement System

FAAH

p62

Hydroxylase

Aminopeptidase

DAPK

MALT

PTEN

GTPase

cAMP

MELK

TOPK

Serotonin Transporter

Decarboxylase

Adenosine Deaminase

APC/C

Lipase

KLF

NEDD8

LTR

NR4A

Porcupine

CD73

ribosome

CRISPR/Cas9

GRK

Bombesin Receptor

ACK1

SGK

CRM1

MRP

PAD

ASK

Protease-activated Receptor

MyD88

Arrestin

FXR

Xanthine Oxidase

KSP

Cadherin

MLK

Factor Xa

GST

Platelet aggregation

FOXO3

Thyroid hormone receptor(THR)

FLAP

PAFR

Haspin Kinase

GPCR19

RSV

Drug-Linker Conjugates for ADC

Protease

PI4K

Factor VIIa

Vitamin

Adiponectin Receptor

ATP Citrate Lyase

E3 Ligase Ligand-Linker Conjugates

Hippo pathway

Sigma receptor

CFTR

Hck

Annexin A

Arp2/3 Complex

Stearoyl-CoA Desaturase (SCD)

HuR

MIF

Neurotensin Receptor

Thrombopoietin Receptor

Cuproptosis

RAR/RXR

DNA gyrase

Acetyl-CoA Carboxylase

FKBP

CaSR

Gap Junction Protein

Lysosomal Autophagy

PARG（Poly(ADP-ribose) Glycohydrolase）

NPC1L1

Kisspeptin

AAK1

LDLR

SIK

Thioredoxin

Beta-Secretase

Glutathione reductase

Liposome

Apelin receptor

CYP19A1

Dynamin

P2Y Receptor

LIM Kinase

DPP-4

HCAR

NEDD4-1

Tight Junction Protein

CD38

VDA

Target Protein Ligand-Linker Conjugates

LAG-3

Monoamine Transporter

PROTAC Linker

Transketolase

Advanced Glycation End Products

NUDIX hydrolase

OCT

Stemness kinase

Na-K-Cl cotransporter

Neuropeptide Y Receptor

SGLT

TMV

Adenylate cyclase

GlyT

PGE Synthase

Urea Transporter

Aquaporin

Melatonin Receptor

Amylase

Prolyl Endopeptidase (PREP)

FABP

LDL

Epoxide Hydrolase

LRRK2

Free radical scavengers

GluCls

RXFP receptor

NADPH-oxidase

Glyoxalase

CAT

Y Box Binding Protein 1

Arginase

Na+/Ca2+ Exchanger

gp120/CD4

Vasopressin Receptor

Carboxypeptidase

Melanocortin Receptor

GHSR

ADC Linker

Poly(ADP-ribose) Glycohydrolase (PARG)

Ferroportin

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