Macrocyclic Compound Database

In the field of drug discovery, there is a burgeoning interest in medium-to-large macrocyclic molecular structures. This is primarily driven by their immense potential as therapeutic modalities for Protein-Protein Interactions (PPIs)—targets traditionally considered "undruggable." Despite their larger size relative to traditional small molecules, macrocycles often exhibit favorable ADME (Absorption, Distribution, Metabolism, and Excretion) and PK (Pharmacokinetic) profiles.