

The conjugation between the antibody and the payload in ADCs is a key determinant of their safety and efficacy.
Antibody–drug conjugates (ADCs) are composed of monoclonal antibodies targeting tumor-associated antigens, conjugated via linkers to varying numbers of small-molecule cytotoxic agents. They combine the high specificity of monoclonal antibody therapeutics with the potent antitumor activity of cytotoxic drugs within tumor tissues.
ADC cytotoxic agents (also known as payloads) are the primary source of cytotoxicity in ADCs. These cytotoxins are the most critical component of an ADC, as they determine its potency in killing cancer cells.
The linker connects the antibody to the cytotoxic payload and is a critical component of antibody–drug conjugates (ADCs). It imparts the following properties to ADCs:
(1) High stability in circulation
(2) Targeted release of the payload in specific tissues.
ADC linkers play a critical role in ADC design, as they connect the cytotoxic drug to the monoclonal antibody. There are two main types of linkers: non-cleavable and cleavable.
Proteolysis-targeting chimera–antibody conjugates (PACs) combine the specificity of antibodies with the protein-degrading capability of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of disease-associated proteins.

Computer-Aided Drug Design (CADD) is a method based on theoretical calculations of molecular structures. It uses computational modeling and simulations to predict interactions between drugs and biological targets, enabling the design and optimization of lead compounds.
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AnyMol leverages advanced CADD technologies—including molecular docking, molecular dynamics simulations, de novo drug design, similarity screening, and 3D-QSAR modeling—to rapidly and efficiently build diverse derivative compound libraries with novel structures, functional diversity, and strong relevance to drug discovery.
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Compound activity screening is a key step in modern drug discovery, aimed at identifying compounds with specific biological activities. It refers to the process of selecting highly active compounds against a particular target or phenotype from large compound collections using standardized experimental approaches. This process integrates multiple technologies into a comprehensive and systematic screening platform.
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AnyMol has an experienced technical team and precise weighing instruments to accurately weigh the various packaged compounds you order and transfer them to standard reagent storage bottles for easier experimentation and storage management.
Compound dissolution can be time-consuming and labor-intensive, especially when handling large libraries. AnyMol provides a dedicated platform for sample preparation, allowing rapid dissolution of large numbers of compounds to specified concentrations, delivering a cost-effective solution for sample processing.
AnyMol offers analytical services including HNMR, LC-MS, and HPLC. By combining multiple analytical techniques, robust quality control can be achieved. With years of experience in compound analysis, AnyMol’s specialists can efficiently verify structure and purity, and provide comprehensive analytical reports.
International shipping of chemicals is often complex and time-intensive, requiring professional handling. AnyMol has extensive experience in logistics and customs clearance, along with standardized operational workflows, ensuring a smooth and hassle-free ordering experience for customers.
