Molecular Glues Compound Database

Molecular glues stabilize or induce the association between E3 ubiquitin ligases and target proteins, triggering target protein degradation (TPD) or functional modulation. This enables the targeting of previously "undruggable" proteins, such as transcription factors and scaffold proteins. In oncology, molecular glues have successfully degraded key oncogenic proteins like BCL6 and IKZF1/3, with data showing an objective response rate (ORR) of 53% in multiple myeloma. In autoimmune diseases, they allow for the precise regulation of inflammatory cytokine signaling pathways. Typically smaller than 500 Da, molecular glues combine the favorable pharmacokinetic profiles of small-molecule drugs with the high specificity of biologics.