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自噬库
TargetMol

Autophagy Compound Library

自噬是一个涉及到细胞自身物质或结构被溶酶体或液泡分解的过程。先是内质网脱落的双层膜包裹细胞内部分受损或老化的细胞器、蛋白质等成分形成自噬体,后与溶酶体或液泡融合降解其所包裹的内容物,以实现细胞本身的代谢需要和某些细胞器的更新。细胞自噬与细胞凋亡、细胞衰老一样,是十分重要的生物学现象,参与生物的发育、生长等多种过程,细胞自噬的异常导致癌细胞的出现。

TargetMol 自噬库集合了文献报道的 1470 种细胞自噬相关的生物活性小分子化合物,可用于细胞自噬机理研究和靶向药物筛选。

  • 陶术生物的所有产品和服务仅用于科学研究,我们不为任何个人用途提供产品和服务。
L3200
产品编号: L3200
  • 规格
  • 1 mg
  • 10 μL x 10 mM (in DMSO)
  • 20 μL x 10 mM (in DMSO)
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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技术资料

产品描述
  • 产品描述:
    • 1470种细胞自噬相关的生物活性小分子化合物的特有集合,包括自噬诱导、自噬抑制,可用于自噬相关的研究,用于高通量、高内涵筛选 ;
    • 产品经过临床验证和临床实验,具有生物安全保障和一定的生物活性 ;
    • 是研究细胞自噬的机理以及药物靶向研究的有效工具 ;
    • 靶点包括蛋白酶体、HIF、E3 Ligase、mTOR等 ;
    • 结构多样,药效显著,可渗透细胞 ;
    • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等 ;
    • NMR和HPLC检测技术保证产品高纯度和高质量 ;
    • 所有化合物现货供应。
  • 包装和储存:
    • 可选用DMSO耐受的96/384孔板或2D 条形码编码管;
    • 干粉蓝冰运输,DMSO溶液干冰运输;
    • 排布:96孔板:1st & 12th 空白对照,384孔板:1st & 2nd & 23th & 24th空白对照。
    • 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求,采用其他溶剂或浓度包装,具体以实际产品信息为准。
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Autophagy
Apoptosis
PI3K
mTOR
Akt
Antibacterial
Endogenous Metabolite
AMPK
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glycosidase
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p62
CRISPR/Cas9
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REV-ERB
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IRE1
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OXPHOS
MLK
NPC1L1
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LPL Receptor
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Ligands for E3 Ligase
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ASK
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Kras
Sigma receptor
Imidazoline Receptor
Cell wall
Necroptosis
RANKL/RANK
Annexin A
GRK
Na-K-Cl cotransporter
Molecular Glues
ACK1
Thrombin
Y Box Binding Protein 1
Arginase
Na+/Ca2+ Exchanger
gp120/CD4
Photosensitizer
NAMPT
Vasopressin Receptor
cAMP
Ephrin Receptor
Aromatase
Gap Junction Protein
IRAK
Apelin receptor
Lipase
Serine Protease
Immunology/Inflammation related
PAFR
Hexokinase
GPCR19
Chloride channel
Melatonin Receptor
Prolyl Endopeptidase (PREP)
DNA gyrase
Guanylate cyclase
MAGL
STING
GluCls
Pyroptosis
Acetyl-CoA Carboxylase
ATTECs
TOPK
Cholecystokinin Receptor
CSF-1R
Myosin
Smo
Endothelin Receptor
Acyltransferase
Decarboxylase
BTK
PGC-1α

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