Epigenetics Compound Library 
Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence. Epigenetics has the potential to be a key element in a paradigm change of our understanding of aging, development, cancer, heart disease, psychological disorders, and other diseases. For example, Epigenetic modifications have a considerable effect on cancer. Changes in the pattern of histone modifications in the promoter sequences as epigenetic regulation lead to changes in chromatin structure thus may be the cause of altered gene expression by activation of oncogenes.
The Epigenetics Compound Library by AnyMol, containing 1500 compounds related to epigenetic regulation, can be used for research in epigenetics, high throughput screening and high content screening for new drugs in epigenetic modification.
- All products & services are for research use only. Not for human or veterinary or therapeutic use.
- Pack Size
- 1 mg
- 10 μL x 10 mM (in DMSO)
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
Technical Information
Library Compound Information
Excel 
SDF - Product Description:
- Quantity: well-chosen 1500 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
- Targets include HDAC, SIRT, HAT, and HMT, etc.;
- Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design;
- NMR and LCMS/HPLC validated to ensure high purity and quality.
- Structurally diverse, medicinally active, and cell permeable;
- NMR and HPLC validated to ensure high purity and quality;
- Advantages Introduction:
High-Standard Entry Criteria
TargetMol’s Epigenetics Compound Library is curated with stringent entry criteria to ensure that every compound in the collection is structurally well-defined and of high purity. Multiple analytical techniques—such as NMR, HPLC, and LCMS—are employed to verify compound integrity. Through a multi-layered screening process, we exclude mixtures, polymers, and other compounds with undefined structures.
Significant Structural Diversity
TargetMol’s Epigenetics Compound Library features remarkable structural diversity, offering significant advantages in drug discovery. Based on an 85% MACCS fingerprint similarity analysis, the library can be divided into 1,052 clusters, covering a wide range of chemical space. The collection encompasses compounds of varying complexity, from simple to intricate chemical structures. This diversity greatly expands the potential for identifying lead compounds with high affinity and specificity toward target proteins, thereby driving drug innovation. Whether addressing traditional drug targets or emerging, more challenging ones, the Epigenetics Library provides a rich source of candidate compounds, accelerating the pace of drug development.
Library Diversity AnalysisSuperior Drug-likeness
71% compounds in this library comply with Lipinski’s “Rule of Five” (Ro5), indicating favorable bioavailability and permeability.
Analysis on Drug-like PropertyMultidimensional Pharmacokinetic Analysis
The Epigenetics Compound Library underwent multidimensional ADMET prediction and evaluation, with a systematic analysis of the following six key pharmacokinetic parameters: blood-brain barrier permeability, cardiac toxicity risk (HERG K+ channel inhibition), plasma protein binding affinity, oral absorption, intestinal absorption, and dermal absorption.
Rich Variety of Compounds
Epigenetic modification refers to the regulation of gene expression without altering the DNA sequence, through mechanisms such as DNA methylation, histone modifications (e.g., methylation, acetylation, deacetylation), and non-coding RNA regulation. These processes play critical roles in pathological conditions including cancer, neurodegenerative diseases, and immune disorders.
TargetMol’s Epigenetic Compound Library is a carefully curated collection of high-quality bioactive small molecules targeting key epigenetic regulators such as Epigenetic Reader Domains, Histone Methyltransferases, HDACs, Sirtuins, Histone Demethylases, Histone Acetyltransferases, DNA Methyltransferases, and MicroRNAs. This library provides comprehensive support for epigenetics research, target validation, and innovative drug discovery.
TargetMol’s Epigenetics Compound Library includes 100+ approved drugs authorized by regulatory agencies such as FDA, EMA, PMDA, and NMPA, as well as 270+ clinical candidates currently in trials. In addition, it features 170+ natural compounds derived from plants, animals, and microorganisms, providing comprehensive support for research on epigenetics-related diseases.
Regular Updates to Compound Libraries
TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.
Flexible Packaging Options
TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.
Personalized Custom Services
TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.
- Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
- Shipped with blue ice
- This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.
