Ferroptosis Compound Library 
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically, biochemically and morphologically distinct from other forms of regulated cell death such as apoptosis, necroptosis, and autophagic cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Understanding the molecular mechanisms and signaling pathways of ferroptosis may provide new diagnostic and therapeutic approaches to regulate cell survival and death in human disease.
AnyMol collects 1240 compounds related to ferroptosis signaling pathway with targets including GPX4, System Xc−, HSPB1, NRF2, VDAC2/3, Ras, TFR1, NOX, p53, CARS, ROS, SLC7A11, etc. Iron chelators and lipid peroxidation inhibitors are also included in this library.
- All products & services are for research use only. Not for human or veterinary or therapeutic use.
- Pack Size
- 1 mg
- 10 μL x 10 mM (in DMSO)
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
Technical Information
Library Compound Information
Excel 
SDF - Product Description:
- A unique collection of 1240 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
- Covers various targets such as GPX4, ROS, p53, Nrf2, etc.；
- Some compounds are FDA approved;
- Detailed compound information with structure, target, and biological activity description；
- NMR and HPLC validated to ensure high purity and quality.
- Packaging And Storage:
- Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
- Shipped with blue ice
- This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.
