Name: STING Agonist 1a
Rating: 5 (10 reviews)

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HIT ID:HIT100015713
Cas No:652142-94-4
常用名:STING Agonist 1a
IUPAC:2-chloro-3-{4-chloro-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl}-6-methoxyquinoline
IUPAC:2-chloro-3-{4-chloro-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl}-6-methoxyquinoline
InChI key:ABGPUQXRCXUIFE-UHFFFAOYSA-N

分子式:C19H11Cl2N5O
分子量:396.23
氢键供体数 (HBD):0
氢键受体数 (HBA):5
LogP:4.37
SMILES:COc1ccc2nc(Cl)c(cc2c1)-c1nnc2c(Cl)nc3ccccc3n12
SMILES:COc1ccc2nc(Cl)c(cc2c1)-c1nnc2c(Cl)nc3ccccc3n12

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

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