Name: p38 MAP Kinase Inhibitor IV
Rating: 5 (10 reviews)

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HIT ID:HIT100136511
Cas No:1638-41-1
常用名:p38 MAP Kinase Inhibitor IV
别名:p38 MAPK Inhibitor IV
IUPAC:3,4,6-trichloro-2-(2,3,5-trichloro-6-hydroxybenzenesulfonyl)phenol
IUPAC:3,4,6-trichloro-2-(2,3,5-trichloro-6-hydroxybenzenesulfonyl)phenol
InChI key:AKUKHICVNCCQHN-UHFFFAOYSA-N

分子式:C12H4Cl6O4S
分子量:456.92
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:8.264
SMILES:Oc1c(Cl)cc(Cl)c(Cl)c1S(=O)(=O)c1c(O)c(Cl)cc(Cl)c1Cl
SMILES:Oc1c(Cl)cc(Cl)c(Cl)c1S(=O)(=O)c1c(O)c(Cl)cc(Cl)c1Cl

p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.

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