Name: MT477
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT100208014
Cas No:328069-91-6
常用名:MT477
IUPAC:2',3',4,5-tetramethyl 6'-[2-(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate
IUPAC:2',3',4,5-tetramethyl 6'-[2-(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate
InChI key:AQFSTZWCFIWEMA-UHFFFAOYSA-N

分子式:C31H30N2O12S3
分子量:718.76
氢键供体数 (HBD):0
氢键受体数 (HBA):14
LogP:3.529
SMILES:COC(=O)C1=C(SC2(S1)C(C(=O)OC)=C(SC1=C2c2cccc(OC)c2N(C(=O)CN2C(=O)CCC2=O)C1(C)C)C(=O)OC)C(=O)OC |c:14,17,t:4|
SMILES:COC(=O)C1=C(SC2(S1)C(C(=O)OC)=C(SC1=C2c2cccc(OC)c2N(C(=O)CN2C(=O)CCC2=O)C1(C)C)C(=O)OC)C(=O)OC |c:14,17,t:4|

MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.

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