Name: Covidcil-19
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT100212444
Cas No:1225177-95-6
常用名:Covidcil-19
IUPAC:3-{[4-(methylamino)quinazolin-2-yl]amino}benzoic acid
IUPAC:3-{[4-(methylamino)quinazolin-2-yl]amino}benzoic acid
InChI key:ATKIOCNKZKNVQS-UHFFFAOYSA-N

分子式:C16H14N4O2
分子量:294.314
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNc1nc(Nc2cccc(c2)C(O)=O)nc2ccccc12
SMILES:CNc1nc(Nc2cccc(c2)C(O)=O)nc2ccccc12

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

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