Name: Arborinine
Rating: 5 (10 reviews)

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HIT ID:HIT100243311
Cas No:5489-57-6
常用名:Arborinine
IUPAC:1-hydroxy-2,3-dimethoxy-10-methyl-9,10-dihydroacridin-9-one
IUPAC:1-hydroxy-2,3-dimethoxy-10-methyl-9,10-dihydroacridin-9-one
InChI key:ATBZZQPALSPNMF-UHFFFAOYSA-N

分子式:C16H15NO4
分子量:285.299
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:1.57
SMILES:COc1cc2n(C)c3ccccc3c(=O)c2c(O)c1OC
SMILES:COc1cc2n(C)c3ccccc3c(=O)c2c(O)c1OC

Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows cytotoxicity against nine drug sensitive and multidrug-resistant cancer cell lines, it also can strongly induce apoptosis in CCRF-CEM cells and cell cycle arrest in the G0/G1 and S phases.

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