Name: C188
Rating: 5 (10 reviews)

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HIT ID:HIT100674516
Cas No:823828-18-8
常用名:C188
别名:STAT3-IN-C188, Cpd-188, Cpd188, C-188, C 188
别名:STAT3-IN-C188, Cpd-188, Cpd188, C-188, C 188
IUPAC:4-({3-[(carboxymethyl)sulfanyl]-4-hydroxynaphthalen-1-yl}sulfamoyl)benzoic acid
IUPAC:4-({3-[(carboxymethyl)sulfanyl]-4-hydroxynaphthalen-1-yl}sulfamoyl)benzoic acid
InChI key:CIERPRDYPKVDJO-UHFFFAOYSA-N

分子式:C19H15NO7S2
分子量:433.45
氢键供体数 (HBD):4
氢键受体数 (HBA):12
LogP:3.0109
SMILES:OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O
SMILES:OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O

C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation.

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