Name: EZ-482
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HIT ID:HIT100805868
Cas No:1016456-76-0
Common Name:EZ-482
alias:EZ482
IUPAC:N-{5-[(3-chlorophenyl)sulfamoyl]-2-hydroxyphenyl}-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
IUPAC:N-{5-[(3-chlorophenyl)sulfamoyl]-2-hydroxyphenyl}-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
InChI key:CLWDCBBEVQRZLY-UHFFFAOYSA-N

Molecular Formula:C23H19ClN4O5S
Molecular Weight:498.94
Hydrogen Bond Donor (HBD):3
Hydrogen Bond Acceptor (HBA):6
LogP:2.546
SMILES:Cn1nc(CC(=O)Nc2cc(ccc2O)S(=O)(=O)Nc2cccc(Cl)c2)c2ccccc2c1=O
SMILES:Cn1nc(CC(=O)Nc2cc(ccc2O)S(=O)(=O)Nc2cccc(Cl)c2)c2ccccc2c1=O

EZ-482 is an apolipoprotein (apoE) ligand that binds to the C-terminal domain of apoE3 and apoE4 through a unique N-terminal allosteric effect, useful in Alzheimer's disease research.

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