Name: Z164597606
Rating: 5 (10 reviews)

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HIT ID:HIT100844376
Cas No:1050587-57-9
常用名:Z164597606
IUPAC:2-{[(furan-2-yl)methyl][(2-nitrophenyl)methyl]amino}-N-phenylacetamide
IUPAC:2-{[(furan-2-yl)methyl][(2-nitrophenyl)methyl]amino}-N-phenylacetamide
InChI key:CMVXDUZFKKRYCX-UHFFFAOYSA-N

分子式:C20H19N3O4
分子量:365.389
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:3.574
SMILES:[O-][N+](=O)c1ccccc1CN(CC(=O)Nc1ccccc1)Cc1ccco1
SMILES:[O-][N+](=O)c1ccccc1CN(CC(=O)Nc1ccccc1)Cc1ccco1

Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2].

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