Name: Mirk-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT100892154
Cas No:1386979-55-0
常用名:Mirk-IN-1
别名:Dyrk1B/A-IN-1
IUPAC:N-(2-chloro-5-{[(3-chlorophenyl)methyl]carbamoyl}phenyl)-2-methoxy-7-oxo-7H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide
IUPAC:N-(2-chloro-5-{[(3-chlorophenyl)methyl]carbamoyl}phenyl)-2-methoxy-7-oxo-7H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide
InChI key:CQKBSRPVZZLCJE-UHFFFAOYSA-N

分子式:C23H17Cl2N5O4
分子量:498.32
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:2.604
SMILES:COc1ncc2cc(C(=O)Nc3cc(ccc3Cl)C(=O)NCc3cccc(Cl)c3)c(=O)[nH]c2n1
SMILES:COc1ncc2cc(C(=O)Nc3cc(ccc3Cl)C(=O)NCc3cccc(Cl)c3)c(=O)[nH]c2n1

Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).

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