Name: MitoBloCK-6
Rating: 4 (6 reviews)

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HIT ID:HIT101048065
Cas No:303215-67-0
Common Name:MitoBloCK-6
IUPAC:2,4-dichloro-6-({[4-(phenylamino)phenyl]imino}methyl)phenol
IUPAC:2,4-dichloro-6-({[4-(phenylamino)phenyl]imino}methyl)phenol
InChI key:DBYOPSAQYAKIQV-UHFFFAOYSA-N

Molecular Formula:C19H14Cl2N2O
Molecular Weight:357.23
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Oc1c(Cl)cc(Cl)cc1C=Nc1ccc(Nc2ccccc2)cc1 |w:9.9|
SMILES:Oc1c(Cl)cc(Cl)cc1C=Nc1ccc(Nc2ccccc2)cc1 |w:9.9|

MitoBloCK-6 is a potent Erv1/ALR inhibitor with IC50 values of 900 nM and 700 nM, respectively, and also inhibits Erv2 with an IC50 of 1.4 μM. Additionally, MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryonic stem cells (hESCs) [1].

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