Name: VU041
Rating: 5 (10 reviews)

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HIT ID:HIT101135070
Cas No:332943-64-3
常用名:VU041
IUPAC:1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]ethan-1-one
IUPAC:1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]ethan-1-one
InChI key:DLAGRCZUELSZFG-UHFFFAOYSA-N

分子式:C19H20F3N3O
分子量:363.384
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:5.021
SMILES:FC(F)(F)c1nn(CC(=O)N2CCCc3ccccc23)c2CCCCc12
SMILES:FC(F)(F)c1nn(CC(=O)N2CCCc3ccccc23)c2CCCCc12

VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1.

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