Name: BHPI
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HIT ID:HIT101283235
Cas No:56632-39-4
Common Name:BHPI
IUPAC:3,3-bis(4-hydroxyphenyl)-7-methyl-2,3-dihydro-1H-indol-2-one
IUPAC:3,3-bis(4-hydroxyphenyl)-7-methyl-2,3-dihydro-1H-indol-2-one
InChI key:FABLAHMQSQFDHR-UHFFFAOYSA-N

Molecular Formula:C21H17NO3
Molecular Weight:331.371
Hydrogen Bond Donor (HBD):3
Hydrogen Bond Acceptor (HBA):2
LogP:3.93
SMILES:Cc1cccc2c1NC(=O)C2(c1ccc(O)cc1)c1ccc(O)cc1
SMILES:Cc1cccc2c1NC(=O)C2(c1ccc(O)cc1)c1ccc(O)cc1

BHPI is a potent inhibitor of nuclear estrogen receptor ERα–regulated gene expression that induces sustained ERα-dependent activation of the endoplasmic reticulum stress sensor and unfolded protein response, leading to persistent inhibition of protein synthesis, and in ERα-positive cancer cells it hyperactivates plasma membrane PLCγ to generate IP3, deplete ER calcium stores via IP3R channels, and convert the normally protective UPR into a toxic response, making BHPI a valuable probe for estrogen signaling and ER stress–based cancer research.

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