Name: NFPS
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT101374463
Cas No:405225-21-0
常用名:NFPS
IUPAC:2-[(3-{[1,1'-biphenyl]-4-yloxy}-3-(4-fluorophenyl)propyl)(methyl)amino]acetic acid
IUPAC:2-[(3-{[1,1'-biphenyl]-4-yloxy}-3-(4-fluorophenyl)propyl)(methyl)amino]acetic acid
InChI key:FDORQEIHOKEJNX-UHFFFAOYSA-N

分子式:C24H24FNO3
分子量:393.458
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:2.2156916
SMILES:CN(CCC(Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O
SMILES:CN(CCC(Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O

NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively).

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