Name: KYA1797
Rating: 5 (10 reviews)

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HIT ID:HIT101494415
Cas No:851304-36-4
常用名:KYA1797
IUPAC:3-[(5Z)-5-{[5-(4-nitrophenyl)furan-2-yl]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
IUPAC:3-[(5Z)-5-{[5-(4-nitrophenyl)furan-2-yl]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
InChI key:FNGXWOIGFSRSSD-ZROIWOOFSA-N

分子式:C17H12N2O6S2
分子量:404.41
氢键供体数 (HBD):1
氢键受体数 (HBA):8
LogP:2.706
SMILES:OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C1=O
SMILES:OC(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C1=O

KYA1797 is an inhibitor of the Wnt/ß-catenin pathway. KYA1797 binds directly to the regulators of G-protein signaling domain of axin, initiats ß-catenin and Ras degradation through enhancement of the ß-catenin destruction complex activating GSK3ß, effectively suppresses the growth of CRCs harboring APC and KRAS mutations.

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