Name: CAY10722
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT102140168
Cas No:388086-13-3
常用名:CAY10722
IUPAC:N-[2-(2,4-dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
IUPAC:N-[2-(2,4-dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
InChI key:HUGVXMJZAPFVHU-UHFFFAOYSA-N

分子式:C21H14Cl2N2O2
分子量:397.26
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:5.5622
SMILES:Clc1ccc(-c2nc3cc(NC(=O)Cc4ccccc4)ccc3o2)c(Cl)c1
SMILES:Clc1ccc(-c2nc3cc(NC(=O)Cc4ccccc4)ccc3o2)c(Cl)c1

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.

市场产品/服务共显示7个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~