Name: Cytarabine 5′-monophosphate
Rating: 5 (10 reviews)

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HIT ID:HIT102266199
Cas No:63-37-6
常用名:Cytarabine 5′-monophosphate
别名:ara-CMP
IUPAC:{[5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
IUPAC:{[5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
InChI key:IERHLVCPSMICTF-UHFFFAOYSA-N

分子式:C9H14N3O8P
分子量:323.198
氢键供体数 (HBD):6
氢键受体数 (HBA):8
LogP:-3.27
SMILES:Nc1ccn(C2OC(COP(O)(O)=O)C(O)C2O)c(=O)n1
SMILES:Nc1ccn(C2OC(COP(O)(O)=O)C(O)C2O)c(=O)n1

Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.

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