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HIT102994692
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HIT102994692
  • HIT ID:HIT102994692
  • Cas No:59-48-3
  • Common Name:Oxindole
  • alias:Indolin-2-one
  • IUPAC:2,3-dihydro-1H-indol-2-one
    IUPAC:2,3-dihydro-1H-indol-2-one
  • InChIKey:JYGFTBXVXVMTGB-UHFFFAOYSA-N
  • Molecular Formula:C8H7NO
  • Molecular Weight:133.15
  • Hydrogen Bond Donor (HBD):1
  • Hydrogen Bond Acceptor (HBA):1
  • LogP:1.18
  • SMILES:O=C1Cc2ccccc2N1
    SMILES:O=C1Cc2ccccc2N1
  • Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.
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