Name: STING Agonist C11
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HIT ID:HIT103064654
Cas No:875863-22-2
Common Name:STING Agonist C11
alias:STING Agonist C11
IUPAC:3-methyl-1-(2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetyl)urea
IUPAC:3-methyl-1-(2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetyl)urea
InChIKey:KQKWXSQTTDLZSO-UHFFFAOYSA-N

Molecular Formula:C19H18N4O3S
Molecular Weight:382.44
Hydrogen Bond Donor (HBD):2
Hydrogen Bond Acceptor (HBA):4
LogP:2.997
SMILES:CNC(=O)NC(=O)C(Sc1nnc(o1)-c1ccc(C)cc1)c1ccccc1
SMILES:CNC(=O)NC(=O)C(Sc1nnc(o1)-c1ccc(C)cc1)c1ccccc1

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC₉₀s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR).

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