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HIT103073742
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HIT103073742
  • HIT ID:HIT103073742
  • Cas No:38485-94-8
  • Common Name:BT317
  • alias:BT-317, BT 317
  • IUPAC:6-chloro-N-(4-methoxyphenyl)-2-oxo-2H-chromene-3-carboxamide
    IUPAC:6-chloro-N-(4-methoxyphenyl)-2-oxo-2H-chromene-3-carboxamide
  • InChIKey:KELHHPZZFSQBQQ-UHFFFAOYSA-N
  • Molecular Formula:C17H12ClNO4
  • Molecular Weight:329.74
  • Hydrogen Bond Donor (HBD):1
  • Hydrogen Bond Acceptor (HBA):4
  • LogP:4.04
  • SMILES:COc1ccc(NC(=O)c2cc3cc(Cl)ccc3oc2=O)cc1
    SMILES:COc1ccc(NC(=O)c2cc3cc(Cl)ccc3oc2=O)cc1
  • BT317 is a brain-penetrant dual inhibitor of mitochondrial LonP1 protease and CT-L proteasome activity. BT317 increases ROS levels, induces apoptosis in astrocytoma cells, and exhibits antitumor effects.
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