Name: Lu AE98134
Rating: 5 (10 reviews)

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HIT ID:HIT103162642
Cas No:849000-18-6
常用名:Lu AE98134
IUPAC:N-butyl-4-methoxy-3-{6-methyl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl}benzene-1-sulfonamide
IUPAC:N-butyl-4-methoxy-3-{6-methyl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl}benzene-1-sulfonamide
InChI key:KLTJHVNRXQKMLY-UHFFFAOYSA-N

分子式:C21H23N5O3S
分子量:425.51
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:3.451
SMILES:CCCCNS(=O)(=O)c1ccc(OC)c(c1)-c1nnc2c3ccccc3c(C)nn12
SMILES:CCCCNS(=O)(=O)c1ccc(OC)c(c1)-c1nnc2c3ccccc3c(C)nn12

Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Nav1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al[1].

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