Name: CAY10760
Rating: 5 (10 reviews)

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HIT ID:HIT103192010
Cas No:391889-85-3
常用名:CAY10760
IUPAC:6-chloro-3-[5-(4-methoxyphenyl)-1-propanoyl-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1,2-dihydroquinolin-2-one
IUPAC:6-chloro-3-[5-(4-methoxyphenyl)-1-propanoyl-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1,2-dihydroquinolin-2-one
InChI key:LAVOKBSCOSIGER-UHFFFAOYSA-N

分子式:C28H24ClN3O3
分子量:485.97
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:5.02
SMILES:CCC(=O)N1N=C(CC1c1ccc(OC)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:5|
SMILES:CCC(=O)N1N=C(CC1c1ccc(OC)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:5|

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .

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