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HIT103198860
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HIT103198860
  • HIT ID:HIT103198860
  • Cas No:518357-51-2
  • Common Name:3-MATIDA
  • IUPAC:5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid
    IUPAC:5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid
  • InChIKey:KOMWRBFEDDEWEP-UHFFFAOYSA-N
  • Molecular Formula:C8H9NO4S
  • Molecular Weight:215.22
  • Hydrogen Bond Donor (HBD):3
  • Hydrogen Bond Acceptor (HBA):5
  • LogP:-1.3808628
  • SMILES:Cc1cc(sc1C(N)C(O)=O)C(O)=O
    SMILES:Cc1cc(sc1C(N)C(O)=O)C(O)=O
  • 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
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