Name: E722-2648
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HIT ID:HIT103269585
Cas No:931963-55-2
Common Name:E722-2648
IUPAC:N-[3-(3-methylpiperidin-1-yl)propyl]-4,8-dithiatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-triene-5-carboxamide
IUPAC:N-[3-(3-methylpiperidin-1-yl)propyl]-4,8-dithiatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-triene-5-carboxamide
InChIKey:KTLYLDMTGYBKTC-UHFFFAOYSA-N

Molecular Formula:C21H30N2OS2
Molecular Weight:390.6
Hydrogen Bond Donor (HBD):1
Hydrogen Bond Acceptor (HBA):4
LogP:4.36
SMILES:CC1CCCN(CCCNC(=O)C2=Cc3sc4CCCCc4c3CS2)C1 |t:12|
SMILES:CC1CCCN(CCCNC(=O)C2=Cc3sc4CCCCc4c3CS2)C1 |t:12|

E722-2648 is a potent inhibitor of the β-catenin/BCL9 complex, specifically preventing its formation and inhibiting Wnt activity. It disrupts cholesterol homeostasis through increased cholesterol esterification and accumulation of lipid droplets. Additionally, E722-2648 exhibits antitumor activity ^[1].

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