Name: Sulindac
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HIT ID:HIT103280186
Cas No:38194-50-2
Common Name:Sulindac
alias:Sulindac sulfoxide, MK-231, Clinoril, Arthrocine
alias:Sulindac sulfoxide, MK-231, Clinoril, Arthrocine
IUPAC:2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid
IUPAC:2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid
InChIKey:MLKXDPUZXIRXEP-MFOYZWKCSA-N

Molecular Formula:C20H17FO3S
Molecular Weight:356.41
Hydrogen Bond Donor (HBD):1
Hydrogen Bond Acceptor (HBA):3
LogP:3.157000000000000e+000
SMILES:CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O |c:1|
SMILES:CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O |c:1|

Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.

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