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HIT103301336
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HIT103301336
  • HIT ID:HIT103301336
  • Cas No:446306-43-0
  • Common Name:MEISi-1
  • alias:MEISi1, MEISi 1
  • IUPAC:4-[(benzylcarbamoyl)methoxy]-N-(2,3-dimethylphenyl)benzamide
    IUPAC:4-[(benzylcarbamoyl)methoxy]-N-(2,3-dimethylphenyl)benzamide
  • InChIKey:MNJQVNZAPZMEDA-UHFFFAOYSA-N
  • Molecular Formula:C24H24N2O3
  • Molecular Weight:388.467
  • Hydrogen Bond Donor (HBD):
  • Hydrogen Bond Acceptor (HBA):
  • LogP:
  • SMILES:Cc1cccc(NC(=O)c2ccc(OCC(=O)NCc3ccccc3)cc2)c1C
    SMILES:Cc1cccc(NC(=O)c2ccc(OCC(=O)NCc3ccccc3)cc2)c1C
  • MEISi-1 is a small-molecule inhibitor targeting the homeodomain of MEIS1 protein. MEISi-1 can significantly inhibit the activity of luciferase reporter genes containing MEIS binding sites, and promote the self-renewal of key hematopoietic stem cells (HSCs) in both mice and humans in vitro and in vivo. It can be used in research on hematological diseases, cardiac regeneration, cancer and other related fields.
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