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- HIT ID:HIT103302026
- Cas No:2441-41-0
- 常用名:N-Palmitoyl Glycine
- InChI key:KVTFEOAKFFQCCX-UHFFFAOYSA-N
- 分子式:C18H35NO3
- 分子量:313.482
- 氢键供体数 (HBD):2
- 氢键受体数 (HBA):3
- LogP:2.46
- The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA; anandamide). N-palmitoyl glycine (PalGly) contains an 18-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100-fold greater amounts in skin and 3-fold greater in brain compared to AEA. Injection of 0.43 μg PalGly in rat hindpaw inhibits heat-induced firing of nociceptive neurons in rat dorsal horn. PalGly treatment induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-sensitive, DRG-like cell line F-11 (EC50 = 5.5 μM).
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- 供应商AA Blocks规格货期4-6周纯度-待询1
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