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HIT103324134
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HIT103324134
  • HIT ID:HIT103324134
  • Cas No:701929-65-9
  • Common Name:Nampt activator-1
  • IUPAC:ethyl 4-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzoate
    IUPAC:ethyl 4-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzoate
  • InChIKey:LNIPYBUMGBKFKQ-UHFFFAOYSA-N
  • Molecular Formula:C16H17N3O3
  • Molecular Weight:299.33
  • Hydrogen Bond Donor (HBD):2
  • Hydrogen Bond Acceptor (HBA):6
  • LogP:2.1328
  • SMILES:CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
    SMILES:CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
  • NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK866-mediated toxicity and is a potential neuroprotective compound.
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