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HIT103342739
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HIT103342739
  • HIT ID:HIT103342739
  • Cas No:314761-14-3
  • Common Name:BTSA1
  • IUPAC:(4E)-3-phenyl-1-(4-phenyl-1,3-thiazol-2-yl)-4-[2-(1,3-thiazol-2-yl)hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-one
    IUPAC:(4E)-3-phenyl-1-(4-phenyl-1,3-thiazol-2-yl)-4-[2-(1,3-thiazol-2-yl)hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-one
  • InChIKey:KYVZVVOQWWCVPP-HKOYGPOVSA-N
  • Molecular Formula:C21H14N6OS2
  • Molecular Weight:430.5
  • Hydrogen Bond Donor (HBD):1
  • Hydrogen Bond Acceptor (HBA):6
  • LogP:6.1419253
  • SMILES:O=C1N(N=C(\C1=N/Nc1nccs1)c1ccccc1)c1nc(cs1)-c1ccccc1 |c:3|
    SMILES:O=C1N(N=C(\C1=N/Nc1nccs1)c1ccccc1)c1nc(cs1)-c1ccccc1 |c:3|
  • BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
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