Name: DC-5163
Rating: 5 (10 reviews)

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HIT ID:HIT103412829
Cas No:897771-47-0
常用名:DC-5163
IUPAC:3-benzyl-N-(3-chloro-4-methoxyphenyl)imidazolidine-1-carbothioamide
IUPAC:3-benzyl-N-(3-chloro-4-methoxyphenyl)imidazolidine-1-carbothioamide
InChI key:MWYSGSPJSNOODI-UHFFFAOYSA-N

分子式:C18H20ClN3OS
分子量:361.89
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:4.3426995
SMILES:COc1ccc(NC(=S)N2CCN(Cc3ccccc3)C2)cc1Cl
SMILES:COc1ccc(NC(=S)N2CCN(Cc3ccccc3)C2)cc1Cl

DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.

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