Name: KCa2 channel modulator 1
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HIT ID:HIT103509449
Cas No:1019106-73-0
Common Name:KCa2 channel modulator 1
IUPAC:N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
IUPAC:N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
InChIKey:LBSKGGZCJBHZET-UHFFFAOYSA-N

Molecular Formula:C16H15ClFN5
Molecular Weight:331.78
Hydrogen Bond Donor (HBD):1
Hydrogen Bond Acceptor (HBA):4
LogP:4.887
SMILES:Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1
SMILES:Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1

KCa2 channel modulator 1 (compound 2o) is an effective, subtype-selective K/Ca2 channel positive modulator that potentiates rat KCa2.2 channels with an EC₅₀ value of 0.99 μM and human KCa2.3 channels with an EC₅₀ value of 0.19 μM ^[1].

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