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HIT103517090
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HIT103517090
  • HIT ID:HIT103517090
  • Cas No:757950-09-7
  • Common Name:Raseglurant
  • alias:ADX-10059, ADX10059, ADX 10059
  • IUPAC:2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethylpyridin-3-amine
    IUPAC:2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethylpyridin-3-amine
  • InChIKey:MEDCLNYIYBERKO-UHFFFAOYSA-N
  • Molecular Formula:C15H13FN2
  • Molecular Weight:240.281
  • Hydrogen Bond Donor (HBD):
  • Hydrogen Bond Acceptor (HBA):
  • LogP:
  • SMILES:Cc1cc(C)c(N)c(n1)C#Cc1cccc(F)c1
    SMILES:Cc1cc(C)c(N)c(n1)C#Cc1cccc(F)c1
  • Raseglurant (ADX-10059) is a negative allosteric modulator of the mGlu5 receptor that demonstrates efficacy against migraine and significantly reduces haloperidol-induced catalepsy in mice, Raseglurant is widely used in neuropharmacology research to study glutamatergic modulation, motor side effects of antipsychotics, and migraine-related signaling pathways.
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