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HIT103519887
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HIT103519887
  • HIT ID:HIT103519887
  • Cas No:312608-54-1
  • Common Name:MID-1
  • IUPAC:4-ethoxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
    IUPAC:4-ethoxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
  • InChIKey:LMDLIMGAGZHZSR-UHFFFAOYSA-N
  • Molecular Formula:C12H11N3O4S
  • Molecular Weight:293.3
  • Hydrogen Bond Donor (HBD):1
  • Hydrogen Bond Acceptor (HBA):8
  • LogP:3.3016
  • SMILES:CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O
    SMILES:CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O
  • MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake
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